Cartagena, Colombia, Close up view of St. Peter Claver
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Southern Caribbean Cruise 7 Nights • Colón, Panama • Serenade of the Seas



Itinerary

Cruise Overview 

Day 1 Sat, Oct 11 Colón, Panama Departs at 4:00 pm

Day 2 Sun, Oct 12 Cartagena, Colombia Docked from 9:00 am - 6:00 pm

Day 3 Mon, Oct 13 Day at Sea Serenade of the Seas

Day 4 Tue, Oct 14 Willemstad, Curacao Docked from 8:00 am - 6:00 pm

Day 5 Wed, Oct 15 Oranjestad, Aruba Docked from 8:00 am - 11:00 pm

Days 6-7 Thu, Oct 16 - Fri, Oct 17 2 Days at Sea Serenade of the Seas

Day 8 Sat, Oct 18 Colón, Panama Arrives at 7:00 am

Cruise Overview 

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Max out memories in the Southern Caribbean on 7 nights of cruising adventure. Set sail from Colón, Panama onboard Serenade of the Seas and head out to explore wow-worthy beaches and crystal-clear waters. Kick back and relax with your crew on this epic getaway.

Side View of Serenade of the Seas Cruise Visiting Bermuda, Norwegian Fjords, Scandinavia
Cartagena, Spain Lighthouse by the Coast
Men and Kids Enjoying a Game of Basketball on the Sports Court
View of a secluded coastal beach in Spain
Cortina Beach in Cartagena, Spain
City hall in Cartagena, Spain

Day 1 Sat, Oct 11, 2025 Colón, Panama Departs at 4:00 pm

Fortifications on the Caribbean Side of Panama in Colon
Wild two-toed sloth hanging on tree in Colon Island, Bocas del Toro, Panama.
View of the Santiago Fortification in Panama
Tropical paradise of sandy beaches with clear blue water in Panama
View at Palm trees, sea and houses in Isla Grande shore. Colon province, Panama
Tropical eco resort with thatched cabins over the sea, Colon island
A cruise from Colon gives you the chance to explore this exciting, small Caribbean province in Panama that’s packed with natural splendor and historical gems. For incredible views, trek through the tropical forests of Portobelo National Park to the impressive 17th century Fort San Lorenzo, which was overtaken by Henry Morgan’s pirates. Visit the town of La Guaira to fuel your senses with traditional dishes, artwork from local artisans, Calypso music and Congo dances. And be sure to check out the Agua Clara Visitor’s Center before you cruise to get a close look at the inner workings of the Panama Canal considered an engineering marvel.
Your ship departs promptly at 4:00 pm, so plan to arrive at least 2-3 hours early to account for checking in and boarding protocols. During this time, many of the ship's amenities are open and operating, so feel free to start your vacation early.
Travel Tips
1
Only in Panama can you watch the sun rise on the Pacific Ocean and set on the Atlantic Ocean. All it takes is a 50-mile taxi ride from one side of the country to the other.

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Day 2 Sun, Oct 12, 2025 Cartagena, Colombia Docked from 9:00 am - 6:00 pm

Cartagena, Spain Lighthouse by the Coast
View of a secluded coastal beach in Spain
Cortina Beach in Cartagena, Spain
City hall in Cartagena, Spain
Cartagena de Indias boasts romantic colonial architecture and a Caribbean coast glittering in shades of bright white and aquamarine. Saunter through the leafy Plaza de Bolivar, photographing multicolored streets like Calle Segunda de Badillo. Cruise to Cartagena to dance to the beat of merengue, salsa and Colombia's very own cumbia at places like Bazurto Social Club. Discover Proclamation Square, where the town people gathered in 1811 in support of the declaration of independence from Spain, and walk the 16th-century fortifications of Castillo San Felipe de Barajas. Enjoy Cartagena's natural grandeur on its many beaches, like Bocagrande, Playa Blanca and placid Rosario Islands National Park, just 45 minutes away from the city.

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Day 3 Mon, Oct 13, 2025 Day at Sea Serenade of the Seas

Family Playing Mini Golf on Liberty of the Seas
A friendly reminder
Make the most of your day at sea by enjoying our Wi-Fi, beverage, and Specialty Dining Packages. These services are available at an additional cost

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Learn more about the ship

Day at sea highlights

Day 4 Tue, Oct 14, 2025 Willemstad, Curacao Docked from 8:00 am - 6:00 pm

Colorful buildings along the coast, Willemstad, Curacao
Shete Boka Park Waves Crashing Coast, Willemstad, Curacao
Christoffel National Park Cactus, Willemstad, Curacao
Discover the colonial-era fortresses and other landmarks of Willemstad on a trolley ride before exploring more on your own. Go on a distillery tour to sample the island’s signature spirit, Blue Curaçao, or make some new marine friends at the Sea Aquarium. Enjoy the island’s stunning turquoise seas on a boat, snorkeling or just relaxing on the sands.
Travel Tips
1
Be sure to catch the swinging Queen Emma Bridge in action from the deck during sailaway.
2
The tap water is safe to drink and refreshingly good thanks to the seawater distillery.

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Day 5 Wed, Oct 15, 2025 Oranjestad, Aruba Docked from 8:00 am - 11:00 pm

Manchebo Beach Coast Sunny Day, Oranjestad, Aruba
Natural Bridge at Blackstone Beach, Oranjestad, Aruba
Divi-Divi Trees by the Beach, Oranjestad, Aruba
Rocky Volcanic Stone Circles of the Natural Pool, "Conchi", Oranjestad, Aruba
Fontein Cave Secluded Beach, Oranjestad, Aruba
Natural Bridge at Blackstone Beach, Oranjestad, Aruba
Fontein Cave Secluded Beach, Oranjestad, Aruba
Oranjestad is best known for its colorful Dutch Colonial ‘gingerbread’ houses painted in bright Caribbean hues, powdery white beaches and crystal-clear aquamarine water. Explore Aruba’s unique geological formations amid desert-like landscapes. Or discover aquatic wonders under the waves on a snorkeling excursion or a thrilling submarine ride. Sun-seekers can choose the beach that best suits their style, from the activity-filled De Palm Island to resort-studded Palm Beach, one of the island’s most glorious stretches of sand.
Travel Tips
1
Free trolleys run in a loop from the port to the downtown area.
2
Locals love lunch, so this is when you’ll find great specials.

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Days 6-7 Thu, Oct 16, 2025 - Fri, Oct 17, 2025 2 Days at Sea Serenade of the Seas

Girls Diving and Swimming in the Covered Pool
A friendly reminder
Make the most of your day at sea by enjoying our Wi-Fi, beverage, and Specialty Dining Packages. These services are available at an additional cost

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Learn more about the ship

Day at sea highlights

Day 8 Sat, Oct 18, 2025 Colón, Panama Arrives at 7:00 am

Fortifications on the Caribbean Side of Panama in Colon
Wild two-toed sloth hanging on tree in Colon Island, Bocas del Toro, Panama.
View of the Santiago Fortification in Panama
Tropical paradise of sandy beaches with clear blue water in Panama
View at Palm trees, sea and houses in Isla Grande shore. Colon province, Panama
Tropical eco resort with thatched cabins over the sea, Colon island
Panama Islands in Boca del Toro
Packed with historical gems and natural beauty, Colon is a small Caribbean province in Panama that’s definitely worth your time to spend a few extra days exploring after your cruise. One of the best things do in Colon is visit the 17th century Fort San Lorenzo which was overtaken by Henry Morgan’s pirates. Continue your adventure with a trek through the tropical forests of Portobelo National Park where you’ll find beautiful coral reefs and countless wildlife. Or consider a day trip to visit the indigenous Emberá community. Be sure to include a stop at the Agua Clara Visitor’s Center on your vacation from Colon to see the inner workings of the Panama Canal, considered an engineering marvel.
The cruise might have ended, but there are still some great activities to enjoy in the area. If you flew into this port, be mindful of your departure flight time and plan accordingly.
Travel Tips
1
Only in Panama can you watch the sun rise on the Pacific Ocean and set on the Atlantic Ocean. All it takes is a 50-mile taxi ride from one side of the country to the other.

Popular excursions

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Your ship:

Serenade of the Seas

Serenade of the Seas Alaska Landscape Aerial
Serenade of the Seas Main Dining Room
Man playing mini golf on a cruise ship open deck.
Chefs Table Crab Wine Tasting
Vintages Wine Friends Enjoying Appetizers
Friends Diving in The Pool
Italian salami, prosciutto, roasted peppers, olives & Gambonzola cheese. Best cruise dining at Giovanni's Table restaurant.
From poolside movie nights and jaw dropping entertainment, to game changing flavors prepared to please your palate, all paths lead to discovery onboard Serenade of the Seas®.
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Ship highlights

What’s included with your vacation

Your vacation essentials are always included. Quench your thirst with water, coffee, juice and tea options available at no charge. Indulge in many delicious free dining options onboard. You can also enjoy jaw-dropping entertainment like live shows, live music, themed dance parties and more at no additional cost.

Suites come with extra amenities and inclusions.

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  • Standard beverages like water, coffee, juice and tea options
  • Food and snacks at our cafes and buffets
  • Shows, live music, and entertainment
  • Most onboard experiences

Snag these upgrades at an additional cost

  • World-class dining at speciality restaurants
  • Cocktails, specialty coffees, sodas and bottled water
  • Wi-Fi to stay connected at sea
  • Spa treatments
  • Shore excursions
  • Professional photography
  • Royal Babies and Tots℠ Nursery
  • Laundry services